Similarly, IL-18 was decreased in patients with metabolic syndrome undergone 12-week combined (endurance and strength) training program (three times a week) (Troseid et al., 2009), in T2DM subjects following a 6-month aerobic moderate-intensity exercise training program (four times/week) (Kadoglou et al., 2007a,b), and 8-week high-intensity exercise training on a rowing ergometer (three times/week), in obese subjects (Leick et al., 2007). The gene discussed is IL18; the disease is type 2 diabetes mellitus.