Anti-VEGF agents, including bevacizumab, ranibizumab, and aflibercept, are the first-line treatment for DME (Brown et al., 2013; Wells et al., 2015) and macular edema secondary to RVO (Boyer et al., 2012; Holz et al., 2013; Schmidt-Erfurth et al., 2019). This evidence concerns the gene VEGFA and macular retinal edema.