Several approaches have been developed to treat macular edema and its underlying causes, such as anti-vascular endothelial growth factor (anti-VEGF) therapies, anti-inflammatory treatments, focal laser photocoagulation, carbonic anhydrase inhibitors, and vitrectomy (Mahdy et al., 2010; Supuran, 2019; Shimura et al., 2020; Aref et al., 2021; Mohan et al., 2021). The gene discussed is VEGFA; the disease is macular retinal edema.