VEGFA and macular retinal edema: These steroids implants or inserts are commonly used as a second-line treatment for DME patients without significant response to anti-VEGF therapies (Tan et al., 2017; He et al., 2018; Fallico et al., 2021), but are also considered as valid therapeutic options in the treatment of RVO-induced macular edema because of their anti-inflammatory, anti-angiogenic, and anti-edema properties (Haller et al., 2010; Haller et al., 2011; Castro-Navarro et al., 2021).