Mechanistically, several studies have reported that fisetin can activate the SIRT1 (Sirtuin 1) signaling pathway in experimental models such as the osteoarthritis model (Zheng et al., 2017), tunicamycin-mediated cell death in PC12 cells (Yen et al., 2017), lead-induced neurotoxicity (Yang et al., 2019), and aging-induced neurodegeneration (Singh et al., 2018). Here, SIRT1 is linked to osteoarthritis.