The target organ for AChEIs is the brain, but as the heart is also rich in cholinesterases, the AChEIs may adversely affect cardiac function due to the cholinergic effects, especially in older patients, resulting in risks of arrhythmias, prolonged time from the start of the Q wave to the end of the T wave (QT-interval), and Torsades de Pointes (TdP) (Isik et al., 2012). The gene discussed is BCHE; the disease is torsades de pointes.