Infection by both viral strains induced an important increase of CXCL10, CCL5, IFNγ, Il-6 and Il-10 expression levels (p < 0.0001) and a moderate increase of Il-1β (p = 0.0014 for G614 strain and p = 0.0281 for Alpha variant) and TNFα (p = 0.0389 for G614 strain and p = 0.0350 for Alpha variant) expressions levels to mock-infected animals (Supplementary Fig. 2). The gene discussed is IFNG; the disease is infection.