SOD1 and serum lipopolysaccharide activity: We used the iNode enrichment analyses to infer the molecular drivers of reactive astrogliosis in four datasets: an LPS-induced mouse model of endotoxemia-associated neuroinflammation, the PS2APP mouse model of AD, the SOD1 G93A mouse model of ALS, and astrocytes isolated from the normal-appearing white matter of human patients with MS.