Other immune and inflammatory factors, including a set of type I and II interferons and their receptors (IFNG, IFNGR, IFNB1, IFNAR1); IRF3; PTGS2; TNF-α and the TNF receptor superfamily; and LIF were also inferred to be upregulated, as well as chemicals/toxins associated with neurodegenerative diseases (beta-amyloid and N-methyl-4-phenylpyridium), whilst the anti-inflammatory glucocorticoid receptor (NR3C1) and its ligand (dexamethasone) were inferred to be downregulated. The gene discussed is IRF3; the disease is neurodegenerative disease.