While circulating IgG3 antibodies in participants with mild infection were maintained at consistent levels throughout the 6-month period (P = 0.062), levels decreased over this time in asymptomatic (P = 0.0022, day <20 vs day 180) and severe (P = 0.021, day <20 vs day 180) individuals (Fig. 2d). The gene discussed is IGHG3; the disease is infection.