Circulating IgM levels decreased over time in those with asymptomatic (P = 0.021, day <20 vs day 180), mild (P = 0.0004, day <20 vs day 180) and severe (P = 0.007, day <20 vs day 180) infection, while IgA levels in participants remained constant in all disease cohorts (asymptomatic: P = 0.65; mild: P = 0.59; severe: P = 0.065), throughout the observed 6-month time course (Figs. 2a, 2b) as previously reported12. Here, CD40LG is linked to infection.