In addition, we silenced KIF26B in METTL3-knockdown HCT116 cells (Fig. 6f) and found that depletion of KIF26B significantly reversed the enhanced cell migration induced by METTL3 knockdown (Fig. 6g), suggesting that KIF26B, at least in partial, mediates the function of METTL3 in CRC aggressiveness. The gene discussed is METTL3; the disease is colorectal carcinoma.