Our data showed that F. nucleatum-treatment decreased the expression of METTL3, while depletion of YAP almost entirely rescued the downregulation of METTL3 expression induced by F. nucleatum (Fig. 2m), implying that YAP signaling is involved in F. nucleatum-induced downregulation of METTL3 expression in CRC cells. This evidence concerns the gene YAP1 and colorectal carcinoma.