YAP1 and colorectal carcinoma: Based on these differential genes, KEGG pathway enrichment analysis revealed that F. nucleatum impacted multiple aspects of CRC cells, including focal adhesion, tight junction, and Hippo signaling pathways (Fig. 4d and Supplementary Fig. 4a, b), which was consistent with our previous data showing a correlation between F. nucleatum and Hippo-YAP signaling.