Since cutC but not cntA was significantly increased in patients with atherosclerosis, we then compared the TMA-producing ability of 5 candidate cutC-containing genera with high R.A. We performed homologous modeling, molecular docking, and dynamic simulation analysis between choline and cutC protein from different strains (specific sequence is shown in Supplementary Table 4). The gene discussed is CUTC; the disease is atherosclerosis.