To further investigate the ScType cell population classification, we studied the associations between the various cell-types based on the occurrence of common SNVs in the cancer consensus genes, and observed that non-malignant cell-types (i.e. memory CD8+ T cells and CD24 + CD66 + neutrophils) were closely similar to each other, while showing almost no SNV similarity with the malignant cell types (e.g. HSC/MPP and ISG+ blast cells, see Fig. 4f). The gene discussed is CD8A; the disease is cancer.