Then, we focused on EOC and found that SIAH1 was remarkably decreased in tumor tissue derived from platinum-resistant (PFS < 6) patients compared with platinum-sensitive (PFS > 6) patients (Fig. 2B and Supplementary Fig. S1C), as well as in EOC patients serum compared with healthy controls (HC) (Fig. 2C). This evidence concerns the gene SIAH1 and neoplasm.