Considering SIAH1 serves as a tumor-inhibiting role in EOC by mediating the ubiquitination and degradation of YBX-1, which acts as a DNA and RNA-binding protein that specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C), promotes the stability of these transcripts, and thus regulates tumor progression. The gene discussed is YBX1; the disease is neoplasm.