In addition, researchers have shown that the expression of SIAH1 is often downregulated or absent in multiple human cancer cell types, including hepatocellular carcinoma, colorectal cancer, breast cancer, lung cancer and bladder cancer [57–59], and plays an important regulatory role in sensitizing multidrug-resistant cells to chemotherapeutic agents [35]. The gene discussed is SIAH1; the disease is urinary bladder cancer.