SIAH1 and cancer: It was shown that decreased SIAH1 mRNA existed in part of the human malignant tumors compared with normal tissues, including EOC (Supplementary Fig S1A), and high SIAH1 expression was significantly related to the improvement of progression-free survival (PFS) in EOC patients (the patients were divided into two groups according to their SIAH1 IHC staining positive rate) (Fig. 2A and Supplementary Fig. S1B).