For example, SIAH1 exerts inhibitory effects on the progression and development of many kinds of malignant tumors, including colorectal cancer, hepatocellular carcinogenesis, breast cancer, and prostate cancer [29, 33, 34], and the ubiquitin ligase activity of SIAH1 largely contributes to its tumor-inhibiting effect. Here, SIAH1 is linked to Familial prostate cancer.