A few studies on this effort have focused on particular genes or pathways such as a large cohort of 12,833 Chinese lung cancer patients from Dr. Lu’s team on the germline EGFR mutations26 and a study led by Dr. Sun et al. on the germline mutations of MMR genes (MLH1, MSH2, MSH6, and PMS2) in a cohort of 1179 Chinese lung cancer patients27. This evidence concerns the gene MLH1 and lung cancer.