Over 100 genes, mostly tumor suppressor genes, have been identified to be accountable for inheritable cancers, a phenomenon termed, genetic predisposition as exampled by germline mutations in BRCA1 and BRCA2 for predisposition of breast cancers, ovary cancers and mismatch repair (MMR) genes for cancers associated with Lynch syndrome1,2. The gene discussed is BRCA2; the disease is ovarian cancer.