Genome-wide Cox regression and Gene Set Enrichment Analysis of data from 530 patients revealed that the Notch network is involved in the progression of Group 3 and Group 4 MB.70 However, Notch signaling appears not to be involved in SHH MBs.71 Notch receptor contains 4 isoforms, i.e., Notch1 – Notch4, which may be differentially involved in the development of MBs. This evidence concerns the gene NOTCH4 and Mobius syndrome.