It has become a trend that the primary definition of non-WNT/SHH subgroup MBs may be replaced by more specific definitions.57 In the present study, we defined a new subtype MBs based on the expression status of Kir2.1/nN2ICD in non-WNT/SHH MBs, in which patients with Kir2.1high/nN2ICDhigh subtype exhibited poorer prognosis than those with non-Kir2.1high/nN2ICDhigh tumors. This evidence concerns the gene KCNJ2 and Mobius syndrome.