Unlike WNT and SHH subgroup MBs, non-WNT/SHH MBs are genetically heterogeneous without specific drivers, key signaling pathways, and mutations in known cancer predisposition genes.57 Recently, several studies have divided non-WNT/SHH MBs into different subtypes based on biological and molecular features through various analytical approaches, parameters, and cohorts. This evidence concerns the gene SHH and cancer.