, through mRNA expression profiling of 64 primary tumor samples, identified inwardly-rectifying potassium channel J2 (KCNJ2/Kir2.1) as one of the most upregulated genes on chromosome 17q in tumors with 17q gain, and suggested that Kir2.1 could be used as a marker of poor prognosis and a therapeutic target in non-WNT/SHH MBs.29 In our previous study of gastric cancer, Kir2.1 was found to significantly enhance the invasion and metastasis of gastric cancer cells by interacting with STK38. The gene discussed is KCNJ2; the disease is gastric cancer.