Our previous study revealed that in gastric cancer (GC) cells, Kir2.1-promoted cell invasion and metastasis via interacting with serine/threonine-protein kinase 38 (STK38) to enhance MEKK2-MEK1/2 -ERK1/2 -Snail signaling.41 This prompted us to examine the effect of kir2.1-overexpression on the MEKK2-MEK1/2-ERK1/2-Snail pathway in MB cells. Here, MAP2K1 is linked to gastric cancer.