Although the association of Kir2.1high with a poorer OS of patients has suggested that Kir2.1high had a potential as a marker for defining a new subtype of non-WNT/SHH MBs, the elucidation of the mechanism of Kir2.1 action in MB prompted us to consider whether the combination of Kir2.1high with Notch2 activation could more effectively define the subtype of non-WNT/SHH MBs. The gene discussed is NOTCH2; the disease is Mobius syndrome.