Results suggested that lower MESH1 mRNA expression was associated with significantly better survivals in patients with renal cell carcinoma (RCC) (Supplementary Fig. 2a), clear cell type RCC (TCGA) (Supplementary Fig. 2b), lung cancers (Supplementary Fig. 2c, d) [16], neuroblastoma (GSE62564) (Supplementary Fig. 2e), colon cancer (GSE38832) [17] (Supplementary Fig. 2f), meningioma (GSE16581) [18] (Supplementary Fig. 2g), and follicular lymphoma (GSE16131) [19] (Supplementary Fig. 2h). Here, HDDC3 is linked to colonic neoplasm.