CASP1 and Cognitive impairment: Protein levels of ASC (Fig. 1F,G; U = 5, p = 0.0028, Mann–Whitney U test), pro-caspase-1 (Fig. 1F,H; U = 1, p = 0.0056, Mann–Whitney U test), and cleaved caspase-1, a NLRP3 complex-free form of caspase-1 (Fig. 1F,I; U = 1, p = 0.0056, Mann–Whitney U test) were upregulated in rTg4510 mice, in accordance with previous reports in other mouse lines of tauopathy (Ising et al., 2019; Stancu et al., 2019), and in the brain or blood of patients with mild cognitive impairment, AD, and FTD (Saresella et al., 2016; Ising et al., 2019).