Data from cancer genomics show that most mutations occur at just three sites in Ras (Gly 12, Gly 13, and Gln 61), with the K-Ras isoform being mutated more frequently than H-Ras or N-Ras (Figure 1—figure supplement 1A, B; Tate et al., 2019). The gene discussed is HRAS; the disease is cancer.