Familial ALS accounts for approximately 10% of cases, which results from genetic alterations in several genes including superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), chromosome 9 open reading frame 72 (C9orf72), and fused in sarcoma (FUS) [2]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.