SOD1 and amyotrophic lateral sclerosis: To determine whether the CMs from ALS patient-iPSCs could have the same neuro-protective effects in vivo, we used transgenic mice engineered to carry the mutant human SOD1 (SOD1G93A) gene, which display progressive degeneration of MNs and the phenotypes of ALS and are used extensively to study human ALS [29, 34, 35], to assess the effects of ALS iPSC secretome in vivo.