Remarkably, the ALS iPSC-CM rescued the agility, coordination, and overall muscle function of the SOD1 mutant mice, delayed the onset of pathological symptoms (Fig. 2a, b), delayed morbidity (Fig. 2c), and improved the neurological scores of the ALS model animals (Fig. 2d). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.