Thus, the present study performed a two-sample Mendelian randomization (2SMR) analysis to assess: i) whether diabetes is causally related to the increased risk of AD; ii) and if so, which diabetes-related physiological parameters, like blood glucose, insulin, and others, is associated with AD; iii) how diabetes drugs can be used as a candidate for the treatment of AD. The gene discussed is INS; the disease is diabetes mellitus.