Among them, genetically predicted the CPE gene could be a protective factor in AD (IVW, OR = 0.94, 95%CI = [0.89, 1.00], p = 0.05, Fig. 4), while the expressions of ETFDH (IVW, OR = 1.08, 95%CI = [1.01,1.16], p = 0.03, Fig. 5), GANC (IVW, OR = 1.09, 95%CI = [1.02,1.18], p = 0.02, Fig. 6), and MGAM (Wald ratio, OR = 1.04, 95%CI = [1.00,1.09], p = 0.04) were causally associated with the increased risk of AD. Here, MGAM is linked to Alzheimer disease.