On auxiliary examinations, AKI group had more serious inflammation responses, worse cardiac and renal function, and severer coagulation system disorders, which manifested as significant increases in CRP, WBC, neutrophils (NE) and PCT, higher levels of BNP, BUN and SCr and lower eGFR level, and the decrease of prothrombin activity and obvious elevation of d-dimer levels. This evidence concerns the gene NPPB and acute kidney injury.