Dose–response proliferation assays in BRAF-mutated MM cell lines (M14 in orange, A375 in red) and in BRAF-mutated THCA (BHT-101 in blue, 8305C in light blue), as shown in Additional file 1: Fig. S2A, demonstrated a significant response in term of reduction of cell viability in response to both NAMPTi (at doses < 10 nM) after 72 h in all BRAF-mutated cell lines compared to control cells. Here, BRAF is linked to Miyoshi myopathy.