To have a formal validation of the direct relationship between over-activation of the BRAF oncogenic pathway and NAMPT expression, two BRAF-WT MM cell lines (MEL505 and Mewo, Fig. 3A, B) and two BRAF-WT THCA cell lines (CAL-62 and ML-1, Fig. 4A, B) were infected with a lentivirus carrying the BRAF V600E construct, leading to the expected constitutive activation of the pathway, with increased baseline ERK phosphorylation (p-ERK) levels (Figs. 3 and 4). The gene discussed is BRAF; the disease is Miyoshi myopathy.