Third, UbcH5c was also involved in many cancer-related signaling pathways, including the p53 signaling pathway [39, 48], p62-mediated autophagy [49], YAP pathway [50], and DNA repair pathways [37], so whether DHPO also inhibits pancreatic cancer via these pathways needs to be further explored. Here, UBE2D3 is linked to pancreatic neoplasm.