Here we show that humanized ISC signature scores (Hu-EphB2-ISC; Hu-Lgr5-ISC), but not non-stemness signature scores such as Hu-Late TA and Hu-Proliferation [29], were significantly associated with tumor progression in 2191 Stage I-IV (primary) and metastatic CRCs (Fig. 4a). The gene discussed is EPHB2; the disease is neoplasm.