Univariate Cox regression analysis showed a significant association between incidence of HCC transformation and alcohol consumption of more than 14 units weekly (HR = 3.117 (95% confidence intervals (CI) 1.121–8.672)), baseline platelet count below the lower limit of normal (HR = 7.259 (95% CI 2.114–24.920)), and baseline serum AFP level above the upper limit of normal (HR = 2.715 (95% CI 1.042–7.074)) (Table 2). The gene discussed is AFP; the disease is hepatocellular carcinoma.