NMDARs show rapid maturation by switching from NR2B- to NR2A-NMDARs during the early development in mice and are prone to MK801-induced schizophrenia-like symptoms [23, 26, 27], And NMDAR antagonists, e.g., phencyclidine (PCP) and MK801, can induce symptoms of schizophrenia in normal human subjects [28]. The gene discussed is GRIN2B; the disease is schizophrenia.