Atypical membranous nephropathy (aMN) is a new type of membranous nephropathy characterized by cells proliferation, multi-site immune complex deposition, most of patients showed ‘full house’ in immunofluorescence, including IgA, IgG, IgM, C3, C1q positive, but no clinical evidence of a secondary cause, also called ‘lupus-like’ membranous nephropathy or ‘full-house’ membranous nephropathy [3,4]. The gene discussed is CD40LG; the disease is membranous glomerulonephritis.