IKZF1 alterations are seen in 70% of Ph‐like BCP‐ALL and loss of IKZF1 function in combination with activated tyrosine kinase signaling, increased IL7R/CRLF2 signaling, and/or JAK/STAT signaling is known to associate with a poor outcome [53]. Here, CRLF2 is linked to acute lymphoblastic leukemia.