Top 10 KEGG pathways included AGE-RAGE signaling pathway in diabetic complications, Amoebiasis, Platelet activation, Relaxin signaling pathway, Diabetic cardiomyopathy, Nicotinate and nicotinamide metabolism, African trypanosomiasis, Carbohydrate digestion and absorption, Endocrine and other factor-regulated calcium reabsorption, Long-term depression. The gene discussed is RENBP; the disease is human African trypanosomiasis.