Eight weeks after infection, 20 mouse serum proteins were up-regulated (various immunoglobulins, apolipoprotein A-II, serum amyloid A-4 protein, afamin, inter-alpha-trypsin inhibitor heavy chain H2, carboxylesterase 1D, lactotransferrin, sialate O-acetylesterase, prothrombin, zinc finger protein DZIP1L and actin-related protein 5) and two were down-regulated (sortilin-related receptor and mitochondrial glutamate dehydrogenase 1). The gene discussed is ITIH2; the disease is infection.