Several reports have suggested a role for Th17 in LN; however, similar to the findings in the human nephritis samples the Accelerating Medicines Partnership in SLE network (AMP consortium) examined (11), no significant Th17 profile was observed by gene signature or Rorc expression in any compartment (Supplemental Figure 3, A and B). This evidence concerns the gene RORC and systemic lupus erythematosus.