EPHX2 and Alzheimer disease: Somemetabolites of arachidonic acid, namely, the epoxyeicosatrienoic acids(EETs), reduce inflammation and attenuate oxidative stress, amongother effects.21 EETs are metabolized byepoxide ring opening to the corresponding diols by the soluble epoxidehydrolase (sEH), upregulated in AD patients,22,23 which terminates the beneficial effects of EETs.