Our results demonstrated that in the codominant model, the ER-CT and TT genotypes of the estrogen receptor-1 (ESR1 PvuII-rs2234693 T>C) gene have no association with the risk and susceptibility to PCOS with OR = 1.04 (95%) CI = (0.422 to 2.56), RR = 1.01 (0.686 to 1.507), p < 0.93. The gene discussed is ESR1; the disease is polycystic ovary syndrome.