The genotype distributions and allele frequencies of the SNPs located in the ESR1 PvuII-rs2234693 T>C showed no deviation in HWE in the PCOS patient group (all p > 0.05) (χ2 = 2.24, p ≤ 0.13) or in healthy controls (all p > 0.05) (χ2 = 0.52, p ≤ 0.47). The gene discussed is ESR1; the disease is polycystic ovary syndrome.