Higher CRP levels (>3 mg/L) emerged to be the most significant univariable marker, which tripled the risk of osteoporosis (OR 3.28 95%CI: 2.65–4.22, p < 0.001) and osteopenia (OR 2.13 95%CI: 1.51–2.84, p = 0.005). This evidence concerns the gene CRP and osteoporosis.