Mood states: POMS (anxiety (+), depression (+), anger (+), confusion (+), vigor (/), fatigue (/));Cardiovascular disease risk biomarkers: BNP (+), ET-1 (+), AGT (/), ANG II (/), AT1 (/), AT2 (+);Inflammatory cytokine: IL-6 (+), TNF-α (/), HCRP (/);Oxidative stress: Serum MDA (+), T-SOD (+). The gene discussed is NPPB; the disease is major depressive disorder.