Mood states: POMS (anxiety (/), depression (+), anger (+), vigor (/), fatigue (+), confusion (+));Blood pressure: SBP (+), DBP (+);Heart rate (/)Inflammatory cytokines: IL-6 (+), TNF-α (/);Cardiovascular disease risk biomarkers: ET-1 (+), AGT (+), Hcy (+), AT1(+), AT2 (+), Renin (/), ANG II(/). The gene discussed is EDN1; the disease is depressive disorder.