Although markers of systemic inflammation such as CRP raise slightly at the beginning of gestation, indicating appropriate placentation [46], a persistent chronic systemic inflammatory response with increased cytokines and CRP levels is associated with placental dysfunction and adverse gestational outcomes [47], including preeclampsia [48], ruptured membranes complicated by chorioamnionitis [49], and preterm labour [50]. Here, CRP is linked to chorioamnionitis.