To this aim, conscious of the role of molecular docking (MD) in the exploration of biomedically-relevant molecular interactions, we conducted an MD study with the program HDOCK [20,21,22,23,24,25] using the 3D structures of NF-kB, IL-17 and IL-36, that are the protein targets involved in psoriasis [26] and those from three plant metabolites found in rivers. The gene discussed is IL17A; the disease is psoriasis.