The human acetylcholine esterase (AChE, PDB ID: 4M0E), monoamine oxidase B (MAO-B; PDB ID: 6FVZ), and Polo-like kinase-2 (PLK2; PDB ID: 4I5P) were selected as three possible pharmacological target proteins for IR3G and IR in the pathway of neuroprotective and anti-Parkinson’s activities. The gene discussed is INSR; the disease is Parkinson disease.