In 1992, it was reported that DM1 is caused by an unstable expansion of CTG (cytosine-thymine-guanine) trinucleotide repeat in the 3′ noncoding region of the Dystrophia Myotonic Protein Kinase gene (DMPK) [3,4], whereas DM2 present an unstable expansion of a tetra-nucleotide CCTG (cytosine-cytosine-thymine-guanine) repeat in the first intron of Cellular Nucleic Acid Binding Protein gene (CNBP, often-termed zinc finger 9 gene -ZNF9-), [5,6]. This evidence concerns the gene DMPK and myotonic dystrophy type 1.