NPPB and type 2 diabetes mellitus: On the contrary, it is worth it to outline that recent studies showed that long-term supplementation with vitamin D(3) did not reduce IL-6, hsCRP or NT-proBNP in patients with type 2 diabetes [149]; additionally, high-dose vitamin D supplementation did not improve biomarkers of glycemia, inflammation, neurohormonal activation or lipids [150].