FLT3 and acute myeloid leukemia: In the management of AML with FLT3 mutations, a number of potential drugs have been investigated including quizartinib (highly selective to FLT3; NCT02039726 and NCT02668653), crenolanib (against both ITD and TKD mutations; NCT02400255) and gilteritinib (potent FLT3/AXL inhibitor; NCT02927262) [18].