The results of our experiments suggest that RTP may lead to increased p53 protein expression in vivo and in vitro, and thereby increase Bax protein expression, inhibit Bc1-2 protein expression, and increase caspase-9 and caspase-3 downstream, thus promoting apoptosis of esophageal squamous cell carcinoma cells and inhibiting tumor growth. This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.