The benificial role of Nrf2 with respect to COX and iNOS signaling is evidenced by aberrant upregulation of COX-2, iNOS, and proinflammatory cytokines, as well as aggravation of non-alcoholic steatohepatitis, in Nrf2 knockout mice [95]. The gene discussed is NOS2; the disease is metabolic dysfunction-associated steatohepatitis.