Finally, in light of the importance of oxidized LDL-LOX-1 signaling pathways in the onset and progression of atherosclerosis, anti-atherogenic strategies that target Mox-LDL-LOX-1 interaction could be promoted as an exciting and promising avenue in developing therapeutic agents to alleviate the atherosclerotic process in humans. The gene discussed is MOXD1; the disease is atherosclerosis.