ACHE and myasthenia gravis: The authors focused on the impairments of the cholinergic system, reporting evidence of dysregulation in acetylcholine (ACh)/acetylcholinesterase (AChE) activities and alteration in ACE2 circulating levels, as observed in myasthenia gravis, ocular myasthenia gravis, noxious skeletal muscles and multisystem inflammatory syndrome [1].