SFPQ and amyotrophic lateral sclerosis: Thus, since SFPQ dysfunction is correlated with diverse neurological diseases, such as amyotrophic lateral sclerosis (ALS) [46,47] and frontotemporal lobar degeneration (FTLD) [48], it is possible to speculate an essential role for this RBP in guaranteeing proper splicing of long introns and thus in maintaining the correct homeostasis of circRNAs in brain physiology and pathology.