As previously described for JAZF1-SUZ12 chimeric RNA, the PAX3-FOXO1 transcript is generated by a chromosomal translocation exclusively in the tumour context, like ARMS [106], while it is probably generated by a post-transcriptional trans-splicing event in healthy cells where the corresponding chromosomal rearrangement at the DNA level was not observed [103,104]. The gene discussed is SUZ12; the disease is neoplasm.