UBE2E3 and neoplasm: CRISPR/Cas9 has been successfully used to generate KO mice for CDR1as, a circRNA involved in synaptic transmission [9], while overexpression of the tumour suppressor circITCH (Itchy E3 ubiquitin protein ligase) elicited protective effects against doxorubicin-induced cardiotoxicity, with potential benefits for cancer patients treated with this anti-tumour agent [208].