AFP and hepatocellular carcinoma: Using comprehensive genetic analysis, we previously classified HCC into two types: stem cell type (hepatic stem cell/hepatoblast-HCC, HpSC-HCC), characterized by epithelial cell adhesion molecule (EpCAM) and AFP positivity, and hepatocyte type (mature hepatocyte-HCC, MH-HCC), characterized by differentiated hepatocyte marker positivity [18].