Regarding the hematopoietic system, ERβ knock-out mice develop a chronic myeloproliferative disease during aging, similar to human chronic myeloid leukemia, uncovering the ERβ involvement in the differentiation of pluripotent hematopoietic progenitor cells [63]. Here, ESR2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.