Phosphorylation of the RelA/p65 domain at the serine 536 (Ser536) residue significantly impacts the stability and protein interactions of NF-κB via a conformational change, and it enhances NF-κB transactivation in response to infection with microbes [52,53,54,55,56,57], but this is not known in HCMV infection. Here, NFKB1 is linked to infection.