It was noted that the mean phospho-tau/tau ratios in the THC 0.02 and 0.2 mg/kg treatment groups were significantly higher than those in the control NTG (p < 0.01 for both THC treatment groups) and TG (p < 0.05 for both THC treatment groups) groups (Figure 7B), suggesting that the phospho-tau/tau ratio is not an appropriate marker for the efficacy of THC in the treatment of AD. Here, MAPT is linked to Alzheimer disease.