PSEN1 and Alzheimer disease: Results of our study confirmed that aged APP/PS1 mice exhibited significantly elevated Aβ production and impaired spatial memory that recapitulated the early-stage AD in humans (Figure 3, Figure 4 and Figure 5 and Figure 6C–G), suggesting that aged APP/PS1 mice are a better model than aged wild-type mice for evaluating the potential of THC in the treatment of AD.