PSEN1 and immune system toxicity: THC treatment at 0.02 and 0.2 mg/kg also had little effect on all of the other cytokines including the IL4, IL6, IL12, and IL17 plasma levels compared with the vehicle treatment in either non-transgenic or APP/PS1 mice, suggesting that THC treatment at 0.02 and 0.2 mg/kg is unlikely to induce any immunotoxicity (Figure 9).