It is common knowledge now that certain EPHAs (EPHA1, EPHA2, EPHA8) and EPHBs (EPHB2, EPHB4) are variably expressed in CRC [52,53,54] specimens, compared with the adjacent normal intestinal tissues, with their expression further being downregulated with CRC progression [54]. This evidence concerns the gene EPHB4 and colorectal carcinoma.