In the MDA-MB-231 breast cancer cell line, the factor VII (FVII) which is a ligand of tissue factor (TF), was shown to enhance the ephrin-A1-mediated activation of the RhoA/ROCK signaling pathway irrespective of PAR-2, inducing a “mesenchymal-to-amoeboid” transformation which could be a metastasis-potentiating event [33]. Here, EFNA1 is linked to breast carcinoma.